The EM algorithm in genetics, genomics and public health

DOI10.1214/08-STS270MaRDI QIDQ906516zbMATH OpenFDO

Authors Nan M. Laird

Publication date 22 January 2016

Published in Statistical Science (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1104.1923, https://projecteuclid.org/euclid.ss/1300108230

zbMATH Keywords

diffusion batteriesfinding regulatory motifsgene countingincomplete datalinkage analysismaximum likelihoodparticle size distributions

Mathematics Subject Classification ID

History of mathematics in the 20th century (01A60) Research exposition (monographs, survey articles) pertaining to statistics (62-02) History of statistics (62-03) Point estimation (62F10) Classification and discrimination; cluster analysis (statistical aspects) (62H30) Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50) Genetics and epigenetics (92D10)

Abstract: The popularity of the EM algorithm owes much to the 1977 paper by Dempster, Laird and Rubin. That paper gave the algorithm its name, identified the general form and some key properties of the algorithm and established its broad applicability in scientific research. This review gives a nontechnical introduction to the algorithm for a general scientific audience, and presents a few examples characteristic of its application.

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Cites work

• A Maximization Technique Occurring in the Statistical Analysis of Probabilistic Functions of Markov Chains
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(5)

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• The EM algorithm and the rise of computational biology

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