A measure of control for secondary cytokine-induced injury of articular cartilage: a computational study

DOI10.1016/J.AMC.2013.07.072zbMATH Open1329.92054arXiv1307.6583OpenAlexW2082429653MaRDI QIDQ907539FDOQ907539

Authors: Jason M. Graham 

Publication date: 25 January 2016

Published in: Applied Mathematics and Computation (Search for Journal in Brave)

Abstract: In previous works, the author and collaborators establish a mathematical model for injury response in articular cartilage. In this paper we use mathematical software and computational techniques, applied to an existing model to explore in more detail how the behavior of cartilage cells is influenced by several of, what are believed to be, the most significant mechanisms underlying cartilage injury response at the cellular level. We introduce a control parameter, the radius of attenuation, and present some new simulations that shed light on how inflammation associated with cartilage injuries impacts the metabolic activity of cartilage cells. The details presented in the work can help to elucidate targets for more effective therapies in the preventative treatment of post-traumatic osteoarthritis.

Full work available at URL: https://arxiv.org/abs/1307.6583

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zbMATH Keywords

inflammationarticular cartilagecytokineschondrocytes

Mathematics Subject Classification ID

Medical applications (general) (92C50)

Cites Work

• The MATLAB ODE Suite
• Title not available (Why is that?)
• Solving DDEs in Matlab

Cited In (2)

• IGF UPTAKE WITH COMPETITIVE BINDING IN ARTICULAR CARTILAGE
• Mathematical modelling of cytokines, MMPs and fibronectin fragments in osteoarthritic cartilage

Uses Software

• Matlab
• ode23
• ode45
• Ode15s
• ode113
• ode23s
• dde23
• MATLAB ODE suite

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