Limit theorems for hybridization reactions on oligonucleotide microarrays

DOI10.1016/J.JMVA.2008.02.014MaRDI QIDQ953864zbMATH OpenOpenAlexFDO

Authors Iwona Pawlikowska, Grzegorz A. Rempala

Publication date 6 November 2008

Published in Journal of Multivariate Analysis (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/0802.1192

zbMATH Keywords

gamma distributionbirth-and-death processdensity-dependent Markov processhybridization reactionLangmuir adsorption-desorption modeloligonucleotide microarray

Mathematics Subject Classification ID

Central limit and other weak theorems (60F05) Signal detection and filtering (aspects of stochastic processes) (60G35) Branching processes (Galton-Watson, birth-and-death, etc.) (60J80)

Abstract: We derive herein the limiting laws for certain stationary distributions of birth-and-death processes related to the classical model of chemical adsorption-desorption reactions due to Langmuir. The model has been recently considered in the context of a hybridization reaction on an oligonucleotide DNA microarray. Our results imply that the truncated gamma- and beta- type distributions can be used as approximations to the observed distributions of the fluorescence readings of the oligo-probes on a microarray. These findings might be useful in developing new model-based, probe-specific methods of extracting target concentrations from array fluorescence readings.

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Cites work

• scientific article; zbMATH DE number 3951715 (Why is no real title available?)
• scientific article; zbMATH DE number 3806623 (Why is no real title available?)
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Cited in

(3)

• Gamma-based clustering via ordered means with application to gene-expression analysis
• Thermodynamics of DNA microarrays
• Statistical Analysis of Adsorption Models for Oligonucleotide Microarrays

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• EBarrays

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