The speed of evolution in large asexual populations

DOI10.1007/S10955-009-9915-XMaRDI QIDQ963295zbMATH OpenOpenAlexFDO

Authors Su-Chan Park, Damien Simon, Joachim Krug

Publication date 19 April 2010

Published in Journal of Statistical Physics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/0910.0219

zbMATH Keywords

clonal interferenceevolutionary dynamicstraveling wavesWright-Fisher model

Mathematics Subject Classification ID

Time-dependent statistical mechanics (dynamic and nonequilibrium) (82C99) Problems related to evolution (92D15) Population dynamics (general) (92D25)

Abstract: We consider an asexual biological population of constant size $N$ evolving in discrete time under the influence of selection and mutation. Beneficial mutations appear at rate $U$ and their selective effects $s$ are drawn from a distribution $g(s)$. After introducing the required models and concepts of mathematical population genetics, we review different approaches to computing the speed of logarithmic fitness increase as a function of $N$, $U$ and $g(s)$. We present an exact solution of the infinite population size limit and provide an estimate of the population size beyond which it is valid. We then discuss approximate approaches to the finite population problem, distinguishing between the case of a single selection coefficient, $g(s)=delta(s-s_b)$, and a continuous distribution of selection coefficients. Analytic estimates for the speed are compared to numerical simulations up to population sizes of order $10^{300}$.

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Cited in

(29)

• Universality classes of interaction structures for NK fitness landscapes
• Evolutionary accessibility in tunably rugged fitness landscapes
• Deterministic evolution of an asexual population under the action of beneficial and deleterious mutations on additive fitness landscapes
• Limiting fitness distributions in evolutionary dynamics
• Dynamics of lineages in adaptation to a gradual environmental change
• A Gaussian particle distribution for branching Brownian motion with an inhomogeneous branching rate
• Estimation of the rate and effect of new beneficial mutations in asexual populations
• Rapid adaptation in large populations with very rare sex: scalings and spontaneous oscillations
• Speed of evolution in large asexual populations with diminishing returns
• Effect of drift, selection and recombination on the equilibrium frequency of deleterious mutations
• Rapid evolution under inertia
• Evolutionary dynamics of a quantitative trait in a finite asexual population
• Greedy adaptive walks on a correlated fitness landscape
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• Statistical questions in experimental evolution
• Quantitative analyses of empirical fitness landscapes
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• Population aging through survival of the fit and stable
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• Absolute negative mobility in evolution
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• Mathematical Properties of a Class of Integro-differential Models from Population Genetics
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• Branching with selection and mutation. I: Mutant fitness of Fréchet type
• Modeling propagation of weakly advantageous mutations in cancer cells
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