Asymptotics of a Brownian ratchet for protein translocation

DOI10.1016/J.SPA.2010.01.018zbMATH Open1190.92007OpenAlexW2056538372MaRDI QIDQ981004FDOQ981004

Authors Andrej Depperschmidt, Peter Pfaffelhuber

Publication date 8 July 2010

Published in Stochastic Processes and their Applications (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/0904.2276

zbMATH Keywords

Brownian motionreflected Brownian motioncumulative processprotein translocationratchet mechanism

Mathematics Subject Classification ID

Point processes (e.g., Poisson, Cox, Hawkes processes) (60G55) Biochemistry, molecular biology (92C40) Brownian motion (60J65) Cell biology (92C37)

Abstract: Protein translocation in cells has been modelled by emph{Brownian ratchets}. In such models, the protein diffuses through a nanopore. On one side of the pore, ratcheting molecules bind to the protein and hinder it to diffuse out of the pore. We study a Brownian ratchet by means of a reflected Brownian motion $(X_t{)}_{tgeq0}$ with a changing reflection point $(R_t{)}_{tgeq0}$. The rate of change of $R_t$ is $gamma(X_t-R_t)$ and the new reflection boundary is distributed uniformly between $R_{t-}$ and $X_t$. The asymptotic speed of the ratchet scales with $gamm{a}^{1/3}$ and the asymptotic variance is independent of $gamma$.

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Cited in

(4)

• Competing islands limit the rate of adaptation in structured populations
• Exact steady-state velocity of ratchets driven by random sequential adsorption
• A Brownian ratchet for protein translocation including dissociation of ratcheting sites
• Asymptotic properties of certain diffusion ratchets with locally negative drift

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