Nonparametric spectral analysis with applications to seizure characterization using EEG time series

DOI10.1214/08-AOAS185zbMATH Open1156.62059arXiv0901.3877MaRDI QIDQ999670FDOQ999670

Authors: Li Qin, Yuedong Wang 

Publication date: 10 February 2009

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

Abstract: Understanding the seizure initiation process and its propagation pattern(s) is a critical task in epilepsy research. Characteristics of the pre-seizure electroencephalograms (EEGs) such as oscillating powers and high-frequency activities are believed to be indicative of the seizure onset and spread patterns. In this article, we analyze epileptic EEG time series using nonparametric spectral estimation methods to extract information on seizure-specific power and characteristic frequency [or frequency band(s)]. Because the EEGs may become nonstationary before seizure events, we develop methods for both stationary and local stationary processes. Based on penalized Whittle likelihood, we propose a direct generalized maximum likelihood (GML) and generalized approximate cross-validation (GACV) methods to estimate smoothing parameters in both smoothing spline spectrum estimation of a stationary process and smoothing spline ANOVA time-varying spectrum estimation of a locally stationary process. We also propose permutation methods to test if a locally stationary process is stationary. Extensive simulations indicate that the proposed direct methods, especially the direct GML, are stable and perform better than other existing methods. We apply the proposed methods to the intracranial electroencephalograms (IEEGs) of an epileptic patient to gain insights into the seizure generation process.

Full work available at URL: https://arxiv.org/abs/0901.3877

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zbMATH Keywords

permutation testsmoothing parameterEEGepilepsysmoothing splinelocally stationary processGACVGMLSS ANOVA

Mathematics Subject Classification ID

Nonparametric estimation (62G05) Nonparametric hypothesis testing (62G10) Time series, auto-correlation, regression, etc. in statistics (GARCH) (62M10) Medical applications (general) (92C50) Inference from stochastic processes and spectral analysis (62M15) Biomedical imaging and signal processing (92C55)

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Cited In (15)

• AdaptSPEC-X: Covariate-Dependent Spectral Modeling of Multiple Nonstationary Time Series
• Characterizing nonlinearity in invasive EEG recordings from temporal lobe epilepsy
• Topological data analysis of single-trial electroencephalographic signals
• Adaptive spectral estimation for nonstationary multivariate time series
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• Nonparametric spectral analysis with applications to seizure characterization using EEG time series
• On detection of epileptic seizure with an approach based on power spectral density with an AR model
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Uses Software

• gss
• astsa

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