Quantitative parameter reconstruction from optical coherence tomographic data

DOI10.1088/1361-6420/AD0FABMaRDI QIDQ6177477zbMATH OpenFDO

Authors Leopold Veselka, Peter Elbau, Leonidas Mindrinos, Lisa Krainz, Wolfgang Drexler

Publication date 17 January 2024

Published in Inverse Problems (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/2306.10938

zbMATH Keywords

Gaussian beam modellayered mediumoptical coherence tomographyquantitative reconstructionrefractive index

Mathematics Subject Classification ID

Partial differential equations of mathematical physics and other areas of application (35Qxx) Miscellaneous topics in partial differential equations (35Rxx) General topics in optics and electromagnetic theory (78Axx)

Abstract: Quantitative tissue information, like the light scattering properties, is considered as a key player in the detection of cancerous cells in medical diagnosis. A promising method to obtain these data is optical coherence tomography (OCT). In this article, we will therefore discuss the refractive index reconstruction from OCT data, employing a Gaussian beam based forward model. We consider in particular samples with a layered structure, meaning that the refractive index as a function of depth is well approximated by a piece-wise constant function. For the reconstruction, we present a layer-by-layer method where in every step the refractive index is obtained via a discretized least squares minimization. For an approximated form of the minimization problem, we present an existence and uniqueness result. The applicability of the proposed method is then verified by reconstructing refractive indices of layered media from both simulated and experimental OCT data.

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