ROCsurvcomp
Implements nonparametric and semiparametric methods for comparing two survival distributions under non-proportional hazards (non-PH) with right, left, or doubly censored data. The methods are based on the Receiver Operating Characteristic (ROC) curve length and its kernel-based estimate (Bantis et al. (2021) <doi:10.1002/sim.8869>) and the overlap coefficient (OVL) and its kernel-based estimate (Schmid and Schmidt (2006) <doi:10.1016/j.csda.2005.01.014>), as well as a new joint inference approach involving both the kernel-based ROC length and the kernel-based OVL. These methods do not require prior knowledge of the underlying non-PH pattern. The methods also accommodate the "last is censored" phenomenon for right-censored data by using flexible parametric approaches only for the portion of the tail of the distribution that corresponds to time values beyond the last observed event (see also Bantis et al. (2017) <doi:10.1002/sim.7394>). The analogous "first is censored" phenomenon is also accommodated for left-censored data.
- Estimation of smooth ROC curves for biomarkers with limits of detection
- Nonparametric estimation of the coefficient of overlapping-theory and empirical application
- The length of the receiver operating characteristic curve and the two cutoff Youden index within a robust framework for discovery, evaluation, and cutoff estimation in biomarker studies involving improper receiver operating characteristic curves
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