Randomized optimal selection design for dose optimization

DOI10.1093/BIOMTC/UJAF124MaRDI QIDQ6905124zbMATH OpenFDO

Authors Shuqi Wang, Ying Yuan, Suyu Liu

Publication date 6 November 2025

Published in Biometrics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1093/BIOMTC/UJAF124

zbMATH Keywords

dose optimizationoptimal designrandomizationselection design

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites work

• A utility-based Bayesian optimal interval (U-BOIN) phase I/II design to identify the optimal biological dose for targeted and immune therapies
• BOP2: Bayesian optimal design for phase II clinical trials with simple and complex endpoints
• Design and sample size determination for multiple-dose randomized phase II trials for dose optimization
• DROID: dose-ranging approach to optimizing dose in oncology drug development

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