Representative subsampling of sedimenting blood

DOI10.1098/RSPA.2019.0223MaRDI QIDQ5160731zbMATH OpenOpenAlexWikidataFDO

Authors Bhargav Rallabandi, Janine K. Nunes, Antonio Perazzo, Sergey Gershtein, Howard A. Stone

Publication date 29 October 2021

Published in Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1902.10105

zbMATH Keywords

biomedical engineeringbloodcomplex fluidsfluid mechanicsKrieger-Doughertymathematical modellingsedimentation

Mathematics Subject Classification ID

Physiological flows (76Z05) Physiological flow (92C35)

Abstract: It is often necessary to extract a small amount of a suspension, such as blood, from a larger sample of the same material for the purposes of diagnostics, testing or imaging. A practical challenge is that blood sediments noticeably on the time scale of a few minutes, making a representative subsampling of the original sample challenging. Guided by experimental data, we develop a Kynch sedimentation model to discuss design considerations that ensure a representative subsampling of blood for the entire range of physiologically relevant hematocrit over a specified time of interest. Additionally, we show that this design may be modified to exploit the sedimentation and subsample either higher or lower hematocrit relative to that of the original sample. Thus, our method provides a simple tool to either concentrate or dilute small quantities of blood or other sedimenting suspensions.

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Cites work

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