rnmamod
A comprehensive suite of functions to perform and visualise pairwise and network meta-analysis with aggregate binary or continuous missing participant outcome data. The package covers core Bayesian one-stage models implemented in a systematic review with multiple interventions, including fixed-effect and random-effects network meta-analysis, meta-regression, and evaluation of the consistency assumption via the node-splitting approach and the unrelated mean effects model (original and revised model proposed by Spineli, (2021) <doi:10.1177/0272989X211068005>). Missing participant outcome data are addressed in all models of the package (see Spineli, (2019) <doi:10.1186/s12874-019-0731-y>, Spineli et al., (2019) <doi:10.1002/sim.8207>, Spineli, (2019) <doi:10.1016/j.jclinepi.2018.09.002>, and Spineli et al., (2021) <doi:10.1177/0962280220983544>). The robustness to primary analysis results can also be investigated using a novel intuitive index (see Spineli et al., (2021) <doi:10.1002/jrsm.1478> and Spineli et al., (2021) <doi:10.1186/s12916-021-02195-y>). Methods to evaluate the transitivity assumption using trial dissimilarities and hierarchical clustering are provided (see Spineli, (2024) <doi:10.1186/s12874-024-02436-7>, and Spineli et al., (2025) <doi:10.1002/sim.70068>). A novel index to facilitate interpretation of local inconsistency is also available (see Spineli, (2024) <doi:10.1186/s13643-024-02680-4> and Spineli, (2025) <doi:10.1186/s13643-025-02984-z>). The package also offers a rich, user-friendly visualisation toolkit that aids in appraising and interpreting the results thoroughly and preparing the manuscript for journal submission. The visualisation tools comprise the network plot, forest plots, panel of diagnostic plots, heatmaps on the extent of missing participant outcome data in the network, league heatmaps on estimation and prediction, rankograms, Bland-Altman plot, leverage plot, deviance scatterplot, heatmap of robustness, barplot of Kullback-Leibler divergence, heatmap of comparison dissimilarities and dendrogram of comparison clustering. The package also allows the user to export the results to an Excel file at the working directory.
- A Revised Framework to Evaluate the Consistency Assumption Globally in a Network of Interventions
- An empirical comparison of Bayesian modelling strategies for missing binary outcome data in network meta-analysis
- An empirical study on 209 networks of treatments revealed intransitivity to be common and multiple statistical tests suboptimal to assess transitivity
- Continuous(ly) missing outcome data in network meta-analysis: A one-stage pattern-mixture model approach
- Exploring the transitivity assumption in network meta-analysis: a novel approach and its implications
- How robust are findings of pairwise and network meta-analysis in the presence of missing participant outcome data?
- Inconsistency was more prevalent than reported: an empirical study of 57 networks with multiple treatments using the node-splitting approach and a novel interpretation index
- Local inconsistency detection using the Kullback–Leibler divergence measure
- Modeling missing binary outcome data while preserving transitivity assumption yielded more credible network meta-analysis results
- Participants' outcomes gone missing within a network of interventions: Bayesian modeling strategies
- Quantifying the robustness of primary analysis results: A case study on missing outcome data in pairwise and network meta‐analysis
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