Screening designs for drug development

DOI10.1093/BIOSTATISTICS/KXL031MaRDI QIDQ5308154zbMATH OpenOpenAlexWikidataFDO

Authors David Rossell, P. Müller, Gary L. Rosner

Publication date 27 September 2007

Published in Biostatistics (Search for Journal in Brave)

Copyright license Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Full work available at URL https://doi.org/10.1093/biostatistics/kxl031

zbMATH Keywords

backward inductionBayesian optimal designclinical trial designforward simulationutility function

Mathematics Subject Classification ID

Bayesian problems; characterization of Bayes procedures (62C10) Sequential statistical methods (62L99) Applications of statistics to biology and medical sciences; meta analysis (62P10)

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Cited in

(10)

• Bayesian designs and the control of frequentist characteristics: a practical solution
• Bayesian Optimal Design for Phase II Screening Trials
• Statistical methodology for screening studies with qualitative/quantitative mixtures
• Decision-theoretic designs for a series of trials with correlated treatment effects using the Sarmanov multivariate beta-binomial distribution
• Phase 2 and 3 Combination Designs to Accelerate Drug Development
• A Review of Modern Computational Algorithms for Bayesian Optimal Design
• Bayes Optimal Informer Sets for Early-Stage Drug Discovery
• A Comparative Tutorial of Bayesian Sequential Design and Reinforcement Learning
• The performance of fixed-horizon, look-ahead procedures compared to backward induction in Bayesian adaptive-randomization decision-theoretic clinical trial design
• Building efficient comparative effectiveness trials through adaptive designs, utility functions, and accrual rate optimization: finding the sweet spot

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