Shape minimization of dendritic attenuation

DOI10.1007/S00245-007-9002-0MaRDI QIDQ2480788zbMATH OpenOpenAlexFDO

Authors Yannick Privat, Antoine Henrot

Publication date 3 April 2008

Published in Applied Mathematics and Optimization (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/math/0702017

zbMATH Keywords

Cable equationDendriteEigenvalue problemOptimal shape

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) Applications of optimal control and differential games (49N90) Numerical optimization and variational techniques (65K10) Neural biology (92C20)

Abstract: What is the optimal shape of a dendrite? Of course, optimality refers to some particular criterion. In this paper, we look at the case of a dendrite sealed at one end and connected at the other end to a soma. The electrical potential in the fiber follows the classical cable equations as established by W. Rall. We are interested in the shape of the dendrite which minimizes either the attenuation in time of the potential or the attenuation in space. In both cases, we prove that the cylindrical shape is optimal.

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Cited in

(3)

• The optimal shape of a dendrite sealed at both ends
• Local optimization of neuron arbors
• An extremal eigenvalue problem arising in heat conduction

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