Simple Designs and Model-Free Tests for Synergy

DOI10.2307/2532796MaRDI QIDQ4842877zbMATH OpenOpenAlexWikidataFDO

Authors Eugene Laska, Morris Meisner, Carole Siegel

Publication date 3 October 1995

Published in Biometrics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.2307/2532796

zbMATH Keywords

agents in combinationantagonismdose-effectdose-response curvesisoboleMin testsimilar actiontesting synergy

Mathematics Subject Classification ID

Nonparametric hypothesis testing (62G10) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Recommendations

• A comparison of several tests for drug synergy
• Parallel dose-response curves in combination experiments.
• An extension of the model free test to test synergy in multiple drug combinations
• Design and analysis of drug combination experiments
• Maximin designs for the detection of synergistic effects

Cited in

(16)

• One-sided tests in generalized linear dose--response models.
• Parallel dose-response curves in combination experiments.
• Lack of synergy regression models
• Practical Design Strategies for the Detection of Drug Synergy
• A Relationship Between two Fundamental Concepts in Drug Combination Theory
• Theorems on Binary Responses to Combinations of Stimuli
• A comparison of several tests for drug synergy
• MODIFICATION OF KELLY AND RICE METHOD FOR SYNERGISM TESTS
• A note on tests for interaction in quantal response data
• An extension of the model free test to test synergy in multiple drug combinations
• Design and analysis of drug combination experiments
• Testing for the Existence of a Desirable Dose Combination
• Asynergistic Regression Based on Maximized Rank Correlation
• Mathematical properties of Hand Incremental Effect Additivity and other synergy theories
• Two-dimensional maximin power designs for combination experiments of drugs
• Compromise design for combination experiment of two drugs

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