simtte

MaRDI QIDQ7373913CRANFDO

Authors Carlos Traynor

Last update 7 November 2026

Copyright license GNU General Public License, version 2.0, GNU General Public License, version 3.0

Software version identifier PACKAGES.rds, 1.0.1, 1.0.2, PACKAGES.rds, 2.0.0

Description

Simulates time-to-event (survival) datasets for clinical trial design and analysis, including datasets driven by a joint pharmacokinetic/pharmacodynamic (PK/PD) model solved via the 'mrgsolve' backend. Event times can be located directly during ODE integration ('in-solver' event detection) using a library of built-in PK/PD hazard models or a user-supplied 'mrgsolve' model converted for this purpose, or generated by inverse transform sampling from a closed-form Weibull or flexible M-spline baseline hazard, or from any externally simulated survival trajectory. See Bender et al. (2005) <doi:10.1002/sim.2059> for the inverse transform sampling methodology and Royston and Parmar (2002) <doi:10.1002/sim.1203> for flexible parametric survival models.

Cites work

• Flexible parametric proportional‐hazards and proportional‐odds models for censored survival data, with application to prognostic modelling and estimation of treatment effects
• Generating survival times to simulate Cox proportional hazards models

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