Single Neuron Computation: From Dynamical System to Feature Detector

DOI10.1162/NECO.2007.19.12.3133MaRDI QIDQ5441729zbMATH OpenOpenAlexDBLPWikidataFDO

Authors Sungho Hong, Blaise Agüera y Arcas, Adrienne L. Fairhall

Publication date 15 February 2008

Published in Neural Computation (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/q-bio/0612025

zbMATH Keywords

Abbott-Kepler modelHodgkin-Huxley modelthreshold crossing models

Mathematics Subject Classification ID

Dynamical systems in biology (37N25) Applications of stochastic analysis (to PDEs, etc.) (60H30) Neural networks for/in biological studies, artificial life and related topics (92B20)

Abstract: White noise methods are a powerful tool for characterizing the computation performed by neural systems. These methods allow one to identify the feature or features that a neural system extracts from a complex input, and to determine how these features are combined to drive the system's spiking response. These methods have also been applied to characterize the input/output relations of single neurons driven by synaptic inputs, simulated by direct current injection. To interpret the results of white noise analysis of single neurons, we would like to understand how the obtained feature space of a single neuron maps onto the biophysical properties of the membrane, in particular the dynamics of ion channels. Here, through analysis of a simple dynamical model neuron, we draw explicit connections between the output of a white noise analysis and the underlying dynamical system. We find that under certain assumptions, the form of the relevant features is well defined by the parameters of the dynamical system. Further, we show that under some conditions, the feature space is spanned by the spike-triggered average and its successive order time derivatives.

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Cites work

• Computation in a Single Neuron: Hodgkin and Huxley Revisited
• Maximum Likelihood Estimation of a Stochastic Integrate-and-Fire Neural Encoding Model
• What Causes a Neuron to Spike?

Cited in

(15)

• Context-dependent coding in single neurons
• Modulation of spike and burst rate in a minimal neuronal circuit with feed-forward inhibition
• A simple white noise analysis of neuronal light responses
• Single neuron as a quantum computer -- morphogenetic neuron
• Type I and Type II Neuron Models Are Selectively Driven by Differential Stimulus Features
• Feature selection in simple neurons: how coding depends on spiking dynamics
• Stimulus features, resetting curves, and the dependence on adaptation
• White Noise Analysis of Coupled Linear-Nonlinear Systems
• Computation in a Single Neuron: Hodgkin and Huxley Revisited
• Might a Single Neuron Solve Interesting Machine Learning Problems Through Successive Computations on Its Dendritic Tree?
• Learning quadratic receptive fields from neural responses to natural stimuli
• Identifying functional bases for multidimensional neural computations
• Functional identification of spike-processing neural circuits
• Two Computational Regimes of a Single-Compartment Neuron Separated by a Planar Boundary in Conductance Space
• A biophysical and statistical modeling paradigm for connecting neural physiology and function

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