GBJ

Generalized Berk-Jones Test for Set-Based Inference in Genetic Association Studies

Last update: 31 January 2024

Copyright license: GNU General Public License, version 3.0

Software version identifier: 0.5.3, 0.4.0, 0.5.0, 0.5.2, 0.5.4

Description

Offers the Generalized Berk-Jones (GBJ) test for set-based inference in geneticassociation studies. The GBJ is designed as an alternative to tests such as Berk-Jones (BJ), Higher Criticism (HC), Generalized Higher Criticism (GHC), Minimum p-value (minP), and Sequence Kernel Association Test (SKAT). All of these other methods (except for SKAT) are also implemented in this package, and we additionally provide an omnibus test (OMNI) which integrates information from each of the tests. The GBJ has been shown to outperform other tests in genetic association studies when signals are correlated and moderately sparse. Please see the vignette for a quickstart guide or Sun and Lin (2017) <arXiv:1710.02469> for more details.

Cites work

Set-Based Tests for Genetic Association Using the Generalized Berk-Jones Statistic

Cited In (3)

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