POSTm

Phylogeny-Guided OTU-Specific Association Test for Microbiome Data

Jung-Ying Tzeng, Caizhi Huang, Shannon T. Holloway

Last update: 13 December 2023

Copyright license: GNU General Public License, version 2.0

Software version identifier: 1.2, 1.1, 1.2, 1.3

Description

Implements the Phylogeny-Guided Microbiome OTU-Specific Association Test method, which boosts the testing power by adaptively borrowing information from phylogenetically close OTUs (operational taxonomic units) of the target OTU. This method is built on a kernel machine regression framework and allows for flexible modeling of complex microbiome effects, adjustments for covariates, and can accommodate both continuous and binary outcomes.

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