cape

Combined Analysis of Pleiotropy and Epistasis for Diversity Outbred Mice

Jake Emerson, Baha El Kassaby, Vivek Philip, Georgi Kolishovski, Anna Tyler, Gregory Carter, Ann Wells

Last update: 9 January 2024

Copyright license: GNU General Public License, version 3.0

Software version identifier: 3.1.1, 1.0, 1.1, 1.2, 1.3, 2.0.1, 2.0.2, 2.0, 3.1.0, 3.1.2

Description

Combined Analysis of Pleiotropy and Epistasis infers predictive networks between genetic variants and phenotypes. It can be used with standard two-parent populations as well as multi-parent populations, such as the Diversity Outbred (DO) mice, Collaborative Cross (CC) mice, or the multi-parent advanced generation intercross (MAGIC) population of Arabidopsis thaliana. It uses complementary information of pleiotropic gene variants across different phenotypes to resolve models of epistatic interactions between alleles. To do this, cape reparametrizes main effect and interaction coefficients from pairwise variant regressions into directed influence parameters. These parameters describe how alleles influence each other, in terms of suppression and enhancement, as well as how gene variants influence phenotypes. All of the final interactions are reported as directed interactions between pairs of parental alleles. For detailed descriptions of the methods used in this package please see the following references. Carter, G. W., Hays, M., Sherman, A. & Galitski, T. (2012) <doi:10.1371/journal.pgen.1003010>. Tyler, A. L., Lu, W., Hendrick, J. J., Philip, V. M. & Carter, G. W. (2013) <doi:10.1371/journal.pcbi.1003270>.

Cites work

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