beadplexr

CRANbeadplexrMaRDI QIDQ113598FDOQ113598

Analysis of Multiplex Cytometric Bead Assays

Ulrik Stervbo

Last update: 16 June 2023

Copyright license: MIT license, File License

Software version identifier: 0.4.1, 0.1.0, 0.2.0, 0.3.0, 0.4.0, 0.5.0

Description

Reproducible and automated analysis of multiplex bead assays such as CBA (Morgan et al. 2004; <doi:10.1016/j.clim.2003.11.017>), LEGENDplex (Yu et al. 2015; <doi:10.1084/jem.20142318>), and MACSPlex (Miltenyi Biotec 2014; Application note: Data acquisition and analysis without the MACSQuant analyzer; <https://www.miltenyibiotec.com/upload/assets/IM0021608.PDF>). The package provides functions for streamlined reading of fcs files, and identification of bead clusters and analyte expression. The package eases the calculation of standard curves and the subsequent calculation of the analyte concentration.

Cites work

• Cytometric bead array: a multiplexed assay platform with applications in various areas of biology
• The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development

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