DRviaSPCN

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Drug Repurposing in Cancer via a Subpathway Crosstalk Network

Junwei Han, Jiashuo Wu

Last update: 13 January 2024

Copyright license: GNU General Public License, version 3.0, GNU General Public License, version 2.0

Software version identifier: 0.1.2, 0.1.0, 0.1.1, 0.1.3, 0.1.4

Description

A systematic biology tool was developed to repurpose drugs via a subpathway crosstalk network. The operation modes include 1) calculating centrality scores of SPs in the context of gene expression data to reflect the influence of SP crosstalk, 2) evaluating drug-disease reverse association based on disease- and drug-induced SPs weighted by the SP crosstalk, 3) identifying cancer candidate drugs through perturbation analysis. There are also several functions used to visualize the results.

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