clinDR

CRANclinDRMaRDI QIDQ128007FDOQ128007

Simulation and Analysis Tools for Clinical Dose Response Modeling

Mike K. Smith, Neal Thomas, Jing Wu

Last update: 9 August 2023

Copyright license: GNU General Public License, version 3.0, GNU General Public License, version 2.0

Software version identifier: 2.3.5, 1.6, 1.7, 1.8, 1.9, 2.2.1, 2.3, 2.4.1

Description

Bayesian and ML Emax model fitting, graphics and simulation for clinical dose response. The summary data from the dose response meta-analyses in Thomas, Sweeney, and Somayaji (2014) <doi:10.1080/19466315.2014.924876> and Thomas and Roy (2016) <doi:10.1080/19466315.2016.1256229> Wu, Banerjee, Jin, Menon, Martin, and Heatherington(2017) <doi:10.1177/0962280216684528> are included in the package. The prior distributions for the Bayesian analyses default to the posterior predictive distributions derived from these references.

Cites work

• Meta-Analysis of Clinical Dose–Response in a Large Drug Development Portfolio
• Analysis of Clinical Dose–Response in Small-Molecule Drug Development: 2009–2014
• Clinical dose–response for a broad set of biological products: A model-based meta-analysis

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