SubtypeDrug
swMATH44748CRANSubtypeDrugMaRDI QIDQ1334257FDOQ1334257
Prioritization of Candidate Cancer Subtype Specific Drugs
Last update: 21 January 2024
Copyright license: GNU General Public License, version 3.0, GNU General Public License, version 2.0
Software version identifier: 0.1.5, 0.1.0, 0.1.1, 0.1.2, 0.1.3, 0.1.4, 0.1.6, 0.1.7
Source code repository: https://github.com/cran/SubtypeDrug
A systematic biology tool was developed to prioritize cancer subtype-specific drugs by integrating genetic perturbation, drug action, biological pathway, and cancer subtype. The capabilities of this tool include inferring patient-specific subpathway activity profiles in the context of gene expression profiles with subtype labels, calculating differentially expressed subpathways based on cultured human cells treated with drugs in the 'cMap' (connectivity map) database, prioritizing cancer subtype specific drugs according to drug-disease reverse association score based on subpathway, and visualization of results (Castelo (2013) <doi:10.1186/1471-2105-14-7>; Han et al (2019) <doi:10.1093/bioinformatics/btz894>; Lamb and Justin (2006) <doi:10.1126/science.1132939>). Please cite using <doi:10.1093/bioinformatics/btab011>.
- GSVA: gene set variation analysis for microarray and RNA-Seq data
- psSubpathway: a software package for flexible identification of phenotype-specific subpathways in cancer progression
- The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
- SubtypeDrug: a software package for prioritization of candidate cancer subtype-specific drugs
This page was built for software: SubtypeDrug
