CompAREdesign

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Statistical Functions for the Design of Studies with Composite Endpoints

Jordi Cortes Martinez, Marta Bofill Roig

Last update: 15 February 2024

Copyright license: GNU General Public License, version 3.0

Software version identifier: 2.2, 1.5, 1.6, 1.7, 1.9, 2.0, 2.1, 2.3.1

Source code repository: https://github.com/cran/CompAREdesign

Description

It has been designed to calculate the required sample size in randomized clinical trials with composite endpoints. It also calculates the expected effect and the probability of observing the composite endpoint, among others. The methodology can be found in Bofill & Gómez (2019) <doi:10.1002/sim.8092> and Gómez & Lagakos (2013) <doi:10.1002/sim.5547>.

Cites work

• A new approach for sizing trials with composite binary endpoints using anticipated marginal values and accounting for the correlation between components
• Statistical considerations when using a composite endpoint for comparing treatment groups

Cited In (1)

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