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CRANcvcrandMaRDI QIDQ138768

Efficient Design and Analysis of Cluster Randomized Trials

Fan Li, Hengshi Yu, Elizabeth L. Turner, John A. Gallis

Last update: 17 September 2023

Copyright license: GNU General Public License, version 3.0, GNU General Public License, version 2.0

Software version identifier: 0.1.0, 0.0.1, 0.0.2, 0.0.3, 0.0.4, 0.1.1

Description

Constrained randomization by Raab and Butcher (2001) <doi:10.1002/1097-0258(20010215)20:3%3C351::AID-SIM797%3E3.0.CO;2-C> is suitable for cluster randomized trials (CRTs) with a small number of clusters (e.g., 20 or fewer). The procedure of constrained randomization is based on the baseline values of some cluster-level covariates specified. The intervention effect on the individual outcome can then be analyzed through clustered permutation test introduced by Gail, et al. (1996) <doi:10.1002/(SICI)1097-0258(19960615)15:11%3C1069::AID-SIM220%3E3.0.CO;2-Q>. Motivated from Li, et al. (2016) <doi:10.1002/sim.7410>, the package performs constrained randomization on the baseline values of cluster-level covariates and clustered permutation test on the individual-level outcomes for cluster randomized trials.

Cites work

• Balance in cluster randomized trials
• ON DESIGN CONSIDERATIONS AND RANDOMIZATION-BASED INFERENCE FOR COMMUNITY INTERVENTION TRIALS
• An evaluation of constrained randomization for the design and analysis of group-randomized trials with binary outcomes

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