Surrogate

Evaluation of Surrogate Endpoints in Clinical Trials

Wim van der Elst, Christoper Weir, Ariel Alonso, Hannah Ensor, Alvaro Poveda, Fenny Ong, Geert Molenberghs, Paul Meyvisch, Florian Stijven

Last update: 20 February 2024

Copyright license: GNU General Public License, version 3.0, GNU General Public License, version 2.0

Software version identifier: 2.8, 0.1-0, 0.1-1, 0.1-2, 0.1-3, 0.1-4, 0.1-5, 0.1-6, 0.1-61, 0.1-62, 0.1-63, 0.1-64, 0.1-66, 0.1-67, 0.1-68, 0.1-69, 0.1-71, 0.1-72, 0.1-73, 0.1-74, 0.1-75, 0.1-76, 0.1-77, 0.1-79, 0.1-801, 0.2, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 3.0, 3.1, 3.2.0, 3.2.1, 3.2.2

Source code repository: https://github.com/cran/Surrogate

Description

In a clinical trial, it frequently occurs that the most credible outcome to evaluate the effectiveness of a new therapy (the true endpoint) is difficult to measure. In such a situation, it can be an effective strategy to replace the true endpoint by a (bio)marker that is easier to measure and that allows for a prediction of the treatment effect on the true endpoint (a surrogate endpoint). The package 'Surrogate' allows for an evaluation of the appropriateness of a candidate surrogate endpoint based on the meta-analytic, information-theoretic, and causal-inference frameworks. Part of this software has been developed using funding provided from the European Union's Seventh Framework Programme for research, technological development and demonstration (Grant Agreement no 602552), the Special Research Fund (BOF) of Hasselt University (BOF-number: BOF2OCPO3), GlaxoSmithKline Biologicals, Baekeland Mandaat (HBC.2022.0145), and Johnson & Johnson Innovative Medicine.

Described by source

An information-theoretic approach for the evaluation of surrogate endpoints based on causal inference

Related Items (6)

An efficient algorithm to assess multivariate surrogate endpoints in a causal inference framework ⋮ On the relationship between the causal‐inference and meta‐analytic paradigms for the validation of surrogate endpoints ⋮ Binary surrogates with stratified samples when weights are unknown ⋮ Generating random correlation matrices with fixed values: an application to the evaluation of multivariate surrogate endpoints ⋮ Statistical evaluation of surrogate endpoints with examples from cancer clinical trials ⋮ Hierarchical models with normal and conjugate random effects : a review

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