EmpiricalCalibration

swMATH16374CRANEmpiricalCalibrationMaRDI QIDQ28244FDOQ28244

Routines for Performing Empirical Calibration of Observational Study Estimates

Marc A. Suchard, Martijn J Schuemie

Last update: 21 December 2023

Copyright license: Apache License, Version 2.0

Software version identifier: 3.1.1, 1.1.0, 1.2.0, 1.3.1, 1.3.6, 1.4.0, 2.0.0, 2.0.1, 2.0.2, 2.1.0, 3.0.0, 3.1.0, 3.1.2

Source code repository: https://github.com/cran/EmpiricalCalibration

Description

Routines for performing empirical calibration of observational study estimates. By using a set of negative control hypotheses we can estimate the empirical null distribution of a particular observational study setup. This empirical null distribution can be used to compute a calibrated p-value, which reflects the probability of observing an estimated effect size when the null hypothesis is true taking both random and systematic error into account. A similar approach can be used to calibrate confidence intervals, using both negative and positive controls. For more details, see Schuemie et al. (2013) <doi:10.1002/sim.5925> and Schuemie et al. (2018) <doi:10.1073/pnas.1708282114>.

Cites work

• Interpreting observational studies: why empirical calibration is needed to correct p ‐values
• Empirical confidence interval calibration for population-level effect estimation studies in observational healthcare data

Cited In (1)

• EvidenceSynthesis

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