nlmixr2est

CRANnlmixr2estMaRDI QIDQ58757

Nonlinear Mixed Effects Models in Population PK/PD, Estimation Routines

Wenping Wang, Vipul Mann, Yuan Xiong, Richard Hooijmaijers, Matthew L. Fidler, Justin J Wilkins, Rik C Schoemaker

Last update: 31 January 2024

Copyright license: GNU General Public License

Software version identifier: 2.1.4, 2.1.5, 2.1.6, 2.0.6, 2.0.7, 2.0.8, 2.1.0, 2.1.1, 2.1.2, 2.1.3, 2.1.6, 2.1.7, 2.1.8, 2.2.0, 2.2.1

Description

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Cites work

• A Tutorial on RxODE: Simulating Differential Equation Pharmacometric Models in R
• Using sensitivity equations for computing gradients of the FOCE and FOCEI approximations to the population likelihood

Related Items (6)

nlmixr2lib ⋮ nlmixr2extra ⋮ nlmixr2plot ⋮ nlmixr2 ⋮ xpose.nlmixr2 ⋮ babelmixr2

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