vaccine

CRANvaccineMaRDI QIDQ5975677FDOQ5975677

Statistical Tools for Immune Correlates Analysis of Vaccine Clinical Trial Data

Avi Kenny

Last update: 16 February 2024

Copyright license: GNU General Public License

Software version identifier: 0.1.0, 1.0.0, 1.1.0, 1.2.0, 1.2.1

Description

Various semiparametric and nonparametric statistical tools for immune correlates analysis of vaccine clinical trial data. This includes calculation of summary statistics and estimation of risk, vaccine efficacy, controlled effects (controlled risk and controlled vaccine efficacy), and mediation effects (natural direct effect, natural indirect effect, proportion mediated). See Gilbert P, Fong Y, Kenny A, and Carone, M (2022) <doi:10.1093/biostatistics/kxac024> and Fay MP and Follmann DA (2023) <doi:10.48550/arXiv.2208.06465>.

Cites work

• A controlled effects approach to assessing immune correlates of protection
• Mediation Analyses for the Effect of Antibodies in Vaccination

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