concrete

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Continuous-Time Competing Risks Estimation using Targeted Minimum Loss-Based Estimation (TMLE)

David Chen

Last update: 10 September 2023

Copyright license: GNU General Public License

Software version identifier: 1.0.5

Description

One-step continuous-time Targeted Minimum Loss-Based Estimation (TMLE) for outcome-specific absolute risk estimands in right-censored survival settings with or without competing risks, implementing the methodology described in Rytgaard et al. (2023) <doi:10.1111/biom.13856> and Rytgaard and van der Laan (2023) <doi:10.1007/s10985-022-09576-2>. Currently 'concrete' can be used to estimate the effects of static or dynamic interventions on binary treatments given at baseline, cross-validated initial estimation of treatment propensity is done using the 'SuperLearner' package, and initial estimation of conditional hazards is done using ensembles of Cox regressions from the 'survival' package or Coxnet from the 'glmnet' package.

Cites work

• Estimation of Time-Specific Intervention Effects on Continuously Distributed Time-to-Event Outcomes by Targeted Maximum Likelihood Estimation
• Targeted maximum likelihood estimation for causal inference in survival and competing risks analysis

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