nlmixr2

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Nonlinear Mixed Effects Models in Population PK/PD

Matthew L. Fidler

Last update: 1 February 2024

Copyright license: GNU General Public License

Software version identifier: 2.0.9, 2.0.6, 2.0.7, 2.0.8, 2.1.0, 2.1.1

Description

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Cites work

• A Tutorial on RxODE: Simulating Differential Equation Pharmacometric Models in R
• Using sensitivity equations for computing gradients of the FOCE and FOCEI approximations to the population likelihood

Cited In (2)

• nlmixr2rpt
• babelmixr2

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