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CRANlrstatMaRDI QIDQ76684FDOQ76684

Power and Sample Size Calculation for Non-Proportional Hazards

Kaifeng Lu

Last update: 22 December 2023

Copyright license: GNU General Public License, version 3.0, GNU General Public License, version 2.0

Software version identifier: 0.1.11, 0.1.12, 0.1.13, 0.1.0, 0.1.1, 0.1.2, 0.1.3, 0.1.4, 0.1.5, 0.1.6, 0.1.7, 0.1.8, 0.1.9, 0.1.10, 0.1.13, 0.1.14, 0.1.15, 0.2.0, 0.2.1, 0.2.2

Description

Performs power and sample size calculation for non-proportional hazards model using the Fleming-Harrington family of weighted log-rank tests. The sequentially calculated log-rank test score statistics are assumed to have independent increments as characterized in Anastasios A. Tsiatis (1982) <doi:10.1080/01621459.1982.10477898>. The mean and variance of log-rank test score statistics are calculated based on Kaifeng Lu (2021) <doi:10.1002/pst.2069>. The boundary crossing probabilities are calculated using the recursive integration algorithm described in Christopher Jennison and Bruce W. Turnbull (2000, ISBN:0849303168).

Cites work

• Repeated Significance Testing for a General Class of Statistics Used in Censored Survival Analysis
• Sample size calculation for logrank test and prediction of number of events over time

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