RNOmni
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Rank Normal Transformation Omnibus Test
Last update: 11 September 2023
Copyright license: GNU General Public License, version 3.0
Software version identifier: 1.0.1, 0.1.2, 0.1.3, 0.1.4, 0.1.5, 0.2.0, 0.2.1, 0.2.2, 0.3.0, 0.4.0, 0.5.0, 0.6.0, 0.7.1, 1.0.0, 1.0.1.2
Inverse normal transformation (INT) based genetic association testing. These tests are recommend for continuous traits with non-normally distributed residuals. INT-based tests robustly control the type I error in settings where standard linear regression does not, as when the residual distribution exhibits excess skew or kurtosis. Moreover, INT-based tests outperform standard linear regression in terms of power. These tests may be classified into two types. In direct INT (D-INT), the phenotype is itself transformed. In indirect INT (I-INT), phenotypic residuals are transformed. The omnibus test (O-INT) adaptively combines D-INT and I-INT into a single robust and statistically powerful approach. See McCaw ZR, Lane JM, Saxena R, Redline S, Lin X. "Operating characteristics of the rank-based inverse normal transformation for quantitative trait analysis in genome-wide association studies" <doi:10.1111/biom.13214>.
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