mmrm
Mixed Models for Repeated Measures
Julia Dedic, Christian Stock, Kevin Kunzmann, Daniel D. Sjoberg, Doug Kelkhoff, Ya Wang, Daniel Sabanes Bove, Jonathan Sidi, Brian Matthew Lang, Dan James, Liming Li, Daniel Leibovitz
Last update: 26 January 2024
Copyright license: Apache License, Version 2.0
Software version identifier: 0.2.2, 0.1.3, 0.1.5, 0.3.6, 0.3.7, 0.3.8, 0.3.9, 0.3.10
Mixed models for repeated measures (MMRM) are a popular choice for analyzing longitudinal continuous outcomes in randomized clinical trials and beyond; see Cnaan, Laird and Slasor (1997) <doi:10.1002/(SICI)1097-0258(19971030)16:20%3C2349::AID-SIM667%3E3.0.CO;2-E> for a tutorial and Mallinckrodt, Lane, Schnell, Peng and Mancuso (2008) <doi:10.1177/009286150804200402> for a review. This package implements MMRM based on the marginal linear model without random effects using Template Model Builder ('TMB') which enables fast and robust model fitting. Users can specify a variety of covariance matrices, weight observations, fit models with restricted or standard maximum likelihood inference, perform hypothesis testing with Satterthwaite or Kenward-Roger adjustment, and extract least square means estimates by using 'emmeans'.
