Rcurvep
CRANRcurvepMaRDI QIDQ99055FDOQ99055
Concentration-Response Data Analysis using Curvep
Tongan Zhao, Jui-Hua Hsieh, Alexander Sedykh
Last update: 9 January 2024
Copyright license: MIT license, File License
Software version identifier: 1.2.1, 1.2.0, 1.3.1
An R interface for processing concentration-response datasets using Curvep, a response noise filtering algorithm. The algorithm was described in the publications (Sedykh A et al. (2011) <doi:10.1289/ehp.1002476> and Sedykh A (2016) <doi:10.1007/978-1-4939-6346-1_14>). Other parametric fitting approaches (e.g., Hill equation) are also adopted for ease of comparison. 3-parameter Hill equation from 'tcpl' package (Filer D et al., <doi:10.1093/bioinformatics/btw680>) and 4-parameter Hill equation from Curve Class2 approach (Wang Y et al., <doi:10.2174/1875397301004010057>) are available. Also, methods for calculating the confidence interval around the activity metrics are also provided. The methods are based on the bootstrap approach to simulate the datasets (Hsieh J-H et al. <doi:10.1093/toxsci/kfy258>). The simulated datasets can be used to derive the baseline noise threshold in an assay endpoint. This threshold is critical in the toxicological studies to derive the point-of-departure (POD).
- tcpl: the ToxCast pipeline for high-throughput screening data
- A Grid Algorithm for High Throughput Fitting of Dose-Response Curve Data
- Use of in Vitro HTS-Derived Concentration–Response Data as Biological Descriptors Improves the Accuracy of QSAR Models of in Vivo Toxicity
- CurveP Method for Rendering High-Throughput Screening Dose-Response Data into Digital Fingerprints
- Application of Benchmark Concentration (BMC) Analysis on Zebrafish Data: A New Perspective for Quantifying Toxicity in Alternative Animal Models
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