Modeling methods for medical systems biology. Regulatory dynamics underlying the emergence of disease processes
type: Item
instance of: scholarly article
title: Modeling methods for medical systems biology. Regulatory dynamics underlying the emergence of disease processes
zbMATH Open document ID: 1406.92002
DOI: 10.1007/978-3-319-89354-9
author: María Elena Álvarez-Buylla Roces
author: J. C. Martínez-García
author: José Dávila-Velderrain
author: Elisa Domínguez-Hüttinger
author: Mariana Esther Martínez-Sánchez
published in: Advances in Experimental Medicine and Biology
publication date: 2019-01-09T00:00:00Z
review text: This book proposes a systems biology approach to biomedicine that implies integrating transcriptional factors and signal transduction pathways, into dynamical regulatory networks. Basic tools, concepts, and methodologies that are used to construct, validate and analyze these mathematical models are presented. Three biomedical examples are given. The approach put forward here constitutes a first step to explore, with a rigorous and formal basis that explicitly considers a complex systems approach, why and how the modulation of the environment or, more broadly, the lifestyle of an individual, may impact the emergence and progression, and eventually the cure, of complex diseases. The approach here may be a useful step to envision novel approaches in health care policy that may aid diminishing the budgetary and the appearance of antimicrobial resistance and waning vaccination. In the first chapter, the authors use a non-formal language to summarize the key concepts and approaches to be developed in the rest of the book. We identify what we refer to as ``core regulatory network modules''. In Chapter 2, graphical as well as relatively simple examples are given to clarify the tools described. Also, the authors provide sources of code and actual programming resources that the reader can access to be able to use the proposed modeling approach to other examples or conditions under study. In Chapter 3, three case studies are given: epithelial cancer, chronic inflammation and atopic dermatitis.
reviewed by: E. Ahmed
Mathematics Subject Classification ID: 92-02
Mathematics Subject Classification ID: 92C42
Mathematics Subject Classification ID: 92C37
Mathematics Subject Classification ID: 92C50
Mathematics Subject Classification ID: 92-04
zbMATH DE Number: 6999250
zbMATH Keywords: system biology
zbMATH Keywords: disease process
zbMATH Keywords: case studies
describes a project that uses: Matlab
describes a project that uses: sbtoolbox
describes a project that uses: BIOCHAM
MaRDI profile type: MaRDI publication profile
full work available at URL: https://doi.org/10.1007/978-3-319-89354-9
OpenAlex ID: W4236324035
description: scientific article; zbMATH DE number 6999250