Modeling blood filtration in hollow fibers dialyzers coupled with patient's body dynamics
type: Item
instance of: scholarly article
title: Modeling blood filtration in hollow fibers dialyzers coupled with patient's body dynamics
zbMATH Open document ID: 1348.76120
DOI: 10.4171/RLM/740
author: Claudio Ronco
author: Francesco Garzotto
author: Jeong Chul Kim
author: Iacopo Borsi
author: Angiolo Farina
author: Antonio Fasano
published in: Atti della Accademia Nazionale dei Lincei. Classe di Scienze Fisiche, Matematiche e Naturali. Serie IX. Rendiconti Lincei. Matematica e Applicazioni
publication date: 2016-11-09T00:00:00Z
review text: Summary: We develop a mathematical model for cross filtration in a hollow fibers dialyzer, taking into account not only the phenomena occurring within the machine, but also the redistribution of chemicals between intra- and extracellular compartments in the patient's body. The scheme for the cross flow is derived with reference to a single fiber, starting from the basic laws of fluid dynamics and exploiting the smallness of the ratio between the fiber radius and the fiber length to obtain significant simplifications. We end up with a system of integral and partial differential equations in which the input data are in principle unknown. Indeed, the blood composition is considerably altered while going through the fiber and the body reacts redistributing urea, sodium ions, etc. between intra- and extracellular compartments with its own dynamics, thus updating the various concentrations at the dialyzer inlet. Such a coupling is an essential feature of the model. We present numerical simulations, showing a reasonable agreement with the data for a specific patient taken from the literature.
Mathematics Subject Classification ID: 76M45
Mathematics Subject Classification ID: 92C50
Mathematics Subject Classification ID: 35Q92
zbMATH DE Number: 6649891
zbMATH Keywords: dialysis
zbMATH Keywords: blood flow
zbMATH Keywords: asymptotic methods
MaRDI profile type: MaRDI publication profile
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description: scientific article; zbMATH DE number 6649891