Dataset for "Implementing a Functional Precision Medicine Tumor Board for Acute Myeloid Leukemia"
type: Item
instance of: data set
description: Article: Implementing a Functional Precision Medicine Tumor Board for Acute Myeloid Leukemia Cancer Discovery, DOI:10.1158/2159-8290.CD-21-0410 Data Types: 1. Clinical summary 2. Drug response data 3. Exome-sequencing data 4. RNA-sequencing data Updates: - FILE:File_3.2. DATE: 28.11.2022. 1. Clinical summary File_0: Common sample annotation including patient and sample IDs, stage of the disease, tissue type and availability of different data types. File_1.1:Clinical data for 186 AML patientsincludingclinical diagnosis, disease classification, gender, age at diagnosis, treatments, cytogenetic and molecular details. The description of the variables/column titles is given below the clinical data. File_1.2: Description of the clinical variables in File_1.1. 2. Drug response data for 164 AML patient samples and 17 healthy samples File_2:Drug library details for 515 chemical compounds. The compound collection includes drugs names, drug class defined by molecular targets or mode of action, concentration range used for drug testing, supplier information, solvent information and vendor information. File_3.1.:Drug response dataincludingselective drug sensitivity scores (sDSS) for 515 compounds across 181 samples (164 AML patient samples and 17 healthy control samples). The DSS is modified area under the curve values and are calculated as shown in Yadav et al publication (1). The selective drug sensitivity scores (sDSS) is healthy control normalized DSS that gives estimated cancer-selective drug responses. The higher the sDSS values indicate drug sensitivities and negative sDSS values represent drug resistance. File_3.2.: Drug response dataincludingdrug sensitivity scores (DSS) and selective drug sensitivity scores (sDSS) for 515 compounds across 181 samples (164 AML patient samples and 17 healthy control samples). The data is identical to the SupplementaryTable 7 in the manuscript. Note: We recommend using selective DSS values instead of raw values (% inhibition, IC50, DSS). …
publication date: 2022-11-02T00:00:00Z
author: Malani Disha
author: Ashwini Kumar
author: Oscar Brück
author: Mika Kontro
author: Bhagwan Yadav
author: Monica Hellesøy
author: Heikki Kuusanmäki
author: Olli Dufva
author: Matti Kankainen
author: Samuli Eldfors
author: Swapnil Potdar
author: Jani Saarela
author: Laura Turunen
author: Imre Västrik
author: Katja Kivinen
author: Janna Saarela
author: Riikka Räty
author: Minna Lehto
author: Bjorn Tore Gjertsen
author: Satu Mustjoki
author: Tero Aittokallio
author: Krister Wennerberg
author: Caroline A. Heckman
author: Olli-Pekka Kallioniemi
author: Kimmo Porkka
Zenodo ID: 7370747
copyright license: Creative Commons Attribution 4.0 International
MaRDI profile type: MaRDI dataset profile
dataset version identifier: lastupdate_31.03.2021_addedFile_3.1
DOI: 10.5281/ZENODO.7370747
description: Dataset published at Zenodo repository.