Hill model (dose-response)
type: Item
instance of: mathematical model
instance of: deterministic model
instance of: dimensional model
instance of: static model
instance of: nonlinear model
community: MathModDB
MaRDI profile type: MaRDI model profile
description: The Hill model in dose–response analysis is an empirical pharmacodynamic model used to represent cooperative activation or inhibition by drugs or ligands. It describes how biological effect increases with concentration in a sigmoidal manner controlled by a cooperativity exponent. The model includes a maximal effect and a half-maximal concentration parameter, providing intuitive measures of efficacy and potency. When the cooperativity exponent equals one, the model reduces to the non-cooperative hyperbolic Emax model. The Hill dose–response model is widely used in pharmacology, toxicology, and pharmacokinetic–pharmacodynamic modeling to analyze concentration–effect relationships.
contains: Hill dose-response equation
used by: nonlinear parameter estimation (Hill dose-response model)
specialized by: Emax model
described by source: Pharmacodynamic principles and the time course of immediate drug effects
named after: Terrell L. Hill
description: sigmoidal model describing cooperative dose–response behavior