nonlinear parameter estimation (Hill dose-response model) (Q6775839)

This task performs nonlinear parameter estimation using dose–response data based on the Hill dose–response model. It estimates the maximal system response, the half-maximal concentration, and the cooperativity exponent by fitting the nonlinear sigmoidal Hill equation directly to observed concentration–effect measurements. Nonlinear regression eliminates distortions from linear transformations and yields robust estimates across a wide range of cooperative behaviors. The resulting parameters describe drug efficacy, potency, and the steepness of the dose–response relationship. This approach is widely used in pharmacology, toxicology, and pharmacokinetic–pharmacodynamic modeling.