Emax model (Q6775840)
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non-cooperative hyperbolic dose–response model
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Emax model |
non-cooperative hyperbolic dose–response model |
Statements
The Emax model in its non-cooperative form is a pharmacodynamic dose–response model that describes how drug effect increases with concentration in a simple hyperbolic manner. It assumes no cooperativity in the system, meaning the Hill coefficient is fixed at one, producing a non-sigmoidal saturation curve. The model is characterized by a maximal achievable effect and the concentration that produces half of this maximum, offering intuitive measures of drug efficacy and potency. As the n = 1 specialization of the Hill dose-response model, it represents the simplest form of saturable concentration–effect behavior. This non-cooperative Emax model is widely used in pharmacology, toxicology, and pharmacokinetic–pharmacodynamic analyses when dose–response relationships do not exhibit sigmoidal characteristics.
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