refineR (Q71515)

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Reference Interval Estimation using Real-World Data
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refineR
Reference Interval Estimation using Real-World Data

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    1.6.0
    8 March 2023
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    1.0.0
    2 August 2021
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    1.5.0
    3 June 2022
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    1.5.1
    19 July 2022
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    1.6.1
    14 November 2023
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    14 November 2023
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    Indirect method for the estimation of reference intervals using Real-World Data ('RWD'). It takes routine measurements of diagnostic tests, containing pathological and non-pathological samples as input and uses sophisticated statistical methods to derive a model describing the distribution of the non-pathological samples. This distribution can then be used to derive reference intervals. Furthermore, the package offers functions for printing and plotting the results of the algorithm. See ?refineR for a more comprehensive description of the features. Version 1.0 of the algorithm is described in detail in 'Ammer et al. (2021)' <doi:10.1038/s41598-021-95301-2>. Additional guidance on the usage of the algorithm is given in 'Ammer et al. (2023)' <doi:10.1093/jalm/jfac101>.
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