Spectral decomposition of atomic structures in heterogeneous cryo-EM

DOI10.1088/1361-6420/ACB2BAMaRDI QIDQ5876570zbMATH OpenOpenAlexFDO

Authors Carlos Esteve-Yagüe, Willem Diepeveen, Ozan Öktem, Carola-Bibiane Schönlieb

Publication date 1 February 2023

Published in Inverse Problems (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/2209.05546

zbMATH Keywords

atomic structure decompositiongraph Laplacianheterogeneous cryo-EMtomographic reconstruction

Mathematics Subject Classification ID

Bayesian inference (62F15) Geometric optics (78A05) Electro- and magnetostatics (78A30) Inverse problems (including inverse scattering) in optics and electromagnetic theory (78A46) Biological applications of optics and electromagnetic theory (78A70) Atomic physics (81V45) Nonconvex programming, global optimization (90C26) Biochemistry, molecular biology (92C40) Biomedical imaging and signal processing (92C55)

Recommendations

• Hyper-molecules: on the representation and recovery of dynamical structures for applications in flexible macro-molecules in cryo-EM
• Cryo-EM reconstruction of continuous heterogeneity by Laplacian spectral volumes
• Covariance matrix estimation for the cryo-EM heterogeneity problem
• Viewing angle classification of cryo-electron microscopy images using eigenvectors
• Three-dimensional structure determination from common lines in cryo-EM by eigenvectors and semidefinite programming

Cites work

• A spectral series approach to high-dimensional nonparametric regression
• Consistency of spectral clustering
• Covariance matrix estimation for the cryo-EM heterogeneity problem
• Cryo-EM reconstruction of continuous heterogeneity by Laplacian spectral volumes
• Feasibility of tomography with unknown view angles
• Finding structure with randomness: probabilistic algorithms for constructing approximate matrix decompositions
• Geometrical structure of Laplacian eigenfunctions
• Le spectre d'une variété riemannienne. (The spectrum of a Riemannian manifold)
• On learning with integral operators
• Rapid solution of the cryo-EM reconstruction problem by frequency marching
• Structural variability from noisy tomographic projections
• Uniqueness of tomography with unknown view angles

Cited in

(4)

• Hyper-molecules: on the representation and recovery of dynamical structures for applications in flexible macro-molecules in cryo-EM
• Cryo-EM reconstruction of continuous heterogeneity by Laplacian spectral volumes
• Covariance matrix estimation for the cryo-EM heterogeneity problem
• Geometric shape matching for recovering protein conformations from single-particle cryo-EM data

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Uses Software

• RELION

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