linear parameter estimation (uni uni reaction without product - Lineweaver Burk model - rapid equilibrium assumption)

Community: MathModDB

computational task

linear task

Available identifiers

MaRDI QIDQ6684582

linear fit to determine the limiting reaction rate and michaelis constant, named after Dean Burk, Hans Lineweaver

List of contained entities

Lineweaver Burk equation (uni uni reaction without product - rapid equilibrium assumption)	$\frac{1}{v_0}=\frac{1}{V_{max,f}}+\frac{K_S}{V_{max,f}}\frac{1}{c_S}$
	$K_S$ represents Michaelis constant substrate (uni uni reaction - rapid equilibrium assumption)
	$V_{max,f}$ represents limiting reaction rate (uni uni reaction - forward)
	$c_S$ represents substrate concentration
	$v_0$ represents initial reaction rate
Michaelis constant substrate (uni uni reaction - rapid equilibrium assumption)	$K_S\equiv \frac{k_{-1}}{k_1}$	output
	$k_{-1}$ represents reaction rate constant
	$k_1$ represents reaction rate constant
	$K_S$ represents Michaelis constant substrate (uni uni reaction - rapid equilibrium assumption)
initial reaction rate
limiting reaction rate (uni uni reaction - forward)	$V_{max,f}\equiv k_2{c}_{E_0}$	output
	$c_{E_0}$ represents enzyme concentration
	$k_2$ represents reaction rate constant
	$V_{max,f}$ represents limiting reaction rate (uni uni reaction - forward)
substrate concentration

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