Nonlinear parameter estimation (uni uni reaction without product and non-competitive complete inhibition - Michaelis Menten model - steady state assumption)

Community: MathModDB

computational task	nonlinear task

Available identifiers

MaRDI QIDQ6684595 FDOQ6684595

Named after

Leonor Michaelis, Maud Menten

Contained entities

initial reaction rate
Michaelis constant substrate (uni uni reaction - steady state assumption)	$K_{S} \equiv \frac{k_{- 1} + k_{2}}{k_{1}}$	output
	$k_{- 1}$ represents reaction rate constant
	$k_{1}$ represents reaction rate constant
	$k_{2}$ represents reaction rate constant
	$K_{S}$ represents Michaelis constant substrate (uni uni reaction - steady state assumption)

limiting reaction rate (uni uni reaction - forward)	$V_{m a x, f} \equiv k_{2} c_{E_{0}}$	output
	$c_{E_{0}}$ represents enzyme concentration
	$k_{2}$ represents reaction rate constant
	$V_{m a x, f}$ represents limiting reaction rate (uni uni reaction - forward)

inhibitor concentration
uncompetitive inhibition constant (uni uni reaction reversible inhibition)	$K_{i u} \equiv \frac{k_{- 4}}{k_{4}}$	output
	$k_{4}$ represents reaction rate constant
	$k_{- 4}$ represents reaction rate constant
	$K_{i u}$ represents uncompetitive inhibition constant (uni uni reaction reversible inhibition)

substrate concentration
competitive inhibition constant (uni uni reaction reversible inhibition)	$K_{i c} \equiv \frac{k_{- 3}}{k_{3}}$	output
	$k_{3}$ represents reaction rate constant
	$k_{- 3}$ represents reaction rate constant
	$K_{i c}$ represents competitive inhibition constant (uni uni reaction reversible inhibition)

Michaelis Menten equation (uni uni reaction without product and non-competitive complete inhibition - steady state assumption)	$v_{0} = \frac{V_{m a x, f} c_{S}}{(1 + \frac{c_{I}}{K_{i c}}) K_{S} + (1 + \frac{c_{I}}{K_{i u}}) c_{S}}$
	$K_{S}$ represents Michaelis constant substrate (uni uni reaction - steady state assumption)
	$K_{i c}$ represents competitive inhibition constant (uni uni reaction reversible inhibition)
	$K_{i u}$ represents uncompetitive inhibition constant (uni uni reaction reversible inhibition)
	$V_{m a x, f}$ represents limiting reaction rate (uni uni reaction - forward)
	$c_{I}$ represents inhibitor concentration
	$c_{S}$ represents substrate concentration
	$v_{0}$ represents initial reaction rate

Further links

Item	Property
nonlinear parameter estimation of enzyme kinetics	specialized by
uni uni reaction non-competitive complete inhibition (Michaelis Menten model without product - steady state assumption)	used by

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