Nonlinear parameter estimation (uni uni reaction without product and non-competitive partial inhibition - Michaelis Menten model - steady state assumption)

Community: MathModDB

computational task	nonlinear task

Available identifiers

MaRDI QIDQ6684613MaRDI QIDQ6684613FDOQ6684613

Contained entities

substrate concentration
uncompetitive inhibition constant (uni uni reaction reversible inhibition)	$K_{i u} \equiv \frac{k_{- 4}}{k_{4}}$	output
	$k_{4}$ represents reaction rate constant
	$k_{- 4}$ represents reaction rate constant
	$K_{i u}$ represents uncompetitive inhibition constant (uni uni reaction reversible inhibition)

limiting reaction rate with inhibitor (uni uni reaction - forward)	$V_{m a x, I, f} \equiv k_{6} c_{E_{0}}$	output
	$c_{E_{0}}$ represents enzyme concentration
	$k_{6}$ represents reaction rate constant
	$V_{m a x, I, f}$ represents limiting reaction rate with inhibitor (uni uni reaction - forward)

initial reaction rate
Michaelis constant substrate (uni uni reaction - steady state assumption)	$K_{S} \equiv \frac{k_{- 1} + k_{2}}{k_{1}}$	output
	$k_{- 1}$ represents reaction rate constant
	$k_{1}$ represents reaction rate constant
	$k_{2}$ represents reaction rate constant
	$K_{S}$ represents Michaelis constant substrate (uni uni reaction - steady state assumption)

limiting reaction rate (uni uni reaction - forward)	$V_{m a x, f} \equiv k_{2} c_{E_{0}}$	output
	$c_{E_{0}}$ represents enzyme concentration
	$k_{2}$ represents reaction rate constant
	$V_{m a x, f}$ represents limiting reaction rate (uni uni reaction - forward)

competitive inhibition constant (uni uni reaction reversible inhibition)	$K_{i c} \equiv \frac{k_{- 3}}{k_{3}}$	output
	$k_{3}$ represents reaction rate constant
	$k_{- 3}$ represents reaction rate constant
	$K_{i c}$ represents competitive inhibition constant (uni uni reaction reversible inhibition)

inhibitor concentration

Computational Task	Algorithmic Task

Further links

Item	Property
nonlinear parameter estimation of enzyme kinetics	specialized by
uni uni reaction non-competitive partial inhibition (Michaelis Menten model without product - steady state assumption)	used by

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