nonlinear parameter estimation (Emax model)

Community: MathModDB

computational task	nonlinear task

Available identifiers

MaRDI QIDQ6775842

nonlinear estimation of Emax model parameters

Description

This task performs nonlinear parameter estimation for the non-cooperative Emax dose–response model. It determines the maximal effect and the half-maximal effective concentration by directly fitting the nonlinear Emax equation to measured concentration–response data. Nonlinear regression avoids the biases associated with linearized transformations and provides accurate estimates of potency and maximal efficacy. The resulting parameters characterize the saturation behavior of the system and the sensitivity of the response to changing concentrations. This approach is widely used in pharmacology and toxicology to quantify drug action under non-cooperative conditions.

List of contained entities

Emax equation	$E = \frac{E_{m a x} c_{D}}{E C_{50} + c_{D}}$
	$E$ represents observed response
	$E_{m a x}$ represents maximal response
	$c_{D}$ represents drug concentration
	$E C_{50}$ represents half maximal effective concentration

drug concentration
half maximal effective concentration
maximal response
observed response

Further items linking to nonlinear parameter estimation (Emax model)

Item	Property
Emax model	used by

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