Testing for Interaction in Studies of Noninferiority

DOI10.1081/BIP-120017729MaRDI QIDQ4796211zbMATH OpenOpenAlexWikidataFDO

Authors Brian L. Wiens, Joseph F. Heyse

Publication date 2 March 2003

Published in Journal of Biopharmaceutical Statistics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1081/bip-120017729

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Testing in survival analysis and censored data (62N03)

Recommendations

• Testing for a treatment-by-stratum interaction in a sequential clinical trial
• Exact tests for negligible interaction in two-way analysis of variance/covariance
• Testing for Qualitative Interactions between Treatment Effects and Patient Subsets
• Non-inferiority of new procedure to standard procedure in stratified matched-pair design
• Testing noninferiority in three‐armed clinical trials based on likelihood ratio statistics

Cites work

• scientific article; zbMATH DE number 4088796 (Why is no real title available?)
• Testing Whether an Identified Treatment Is Best
• Testing for Qualitative Interactions between Treatment Effects and Patient Subsets

Cited in

(5)

• Exact tests for negligible interaction in two-way analysis of variance/covariance
• Testing interaction between treatment and high‐dimensional covariates in randomized clinical trials
• Testing for a treatment-by-stratum interaction in a sequential clinical trial
• Subgroup discovery in non-inferiority trials
• Issues of Simultaneous Tests for Noninferiority and Superiority

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