Testing the Statistical Certainty of a Response to Increasing Doses of a Drug

DOI10.2307/2530666MaRDI QIDQ4720628zbMATH OpenOpenAlexWikidataFDO

Authors John W. Tukey, Joseph L. Ciminera, Joseph F. Heyse

Publication date 1985

Published in Biometrics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.2307/2530666

zbMATH Keywords

dose-responseno- statistical-significance-of-trend dosetest proceduretoxicity studiestrend test

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

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Cited in

(21)

• John W. Tukey's contributions to multiple comparisons
• A flexible fixed-sequence testing method for hierarchically ordered correlated multiple endpoints in clinical trials
• Dose response signal detection under model uncertainty
• Exploratory analysis of the effects of ultra-molecolar arsenic trioxide on wheat seedling growth in vitro
• Stepwise Confidence Intervals for Monotone Dose–Response Studies
• Determination of sample sizes for demonstrating efficacy of radiation countermeasures
• Simultaneous confidence bounds in monotone dose-response studies
• IDENTIFYING THE MAXIMUM SAFE DOSE: A MULTIPLE TESTING APPROACH
• Step-down trend tests for identifying the minimum effective dose
• On sequential closed testing dose groups with a control
• Comparison of different approaches for dose response analysis
• Improved power of familywise error rate procedures for discrete data under dependency
• Adjusted Regression Trend Test for a Multicenter Clinical Trial
• Nonparametric Identification of the Minimum Effective Dose
• Statistical Method for Analysis of the Disease Curve in Animals with Experimental Autoimmune Encephalomyelitis
• Biostatistical assessment of mutagenicity studies by including the positive control
• A comparative study of different methodologies for fault diagnosis in multivariate quality control
• Combining Multiple Comparisons and Modeling Techniques in Dose‐Response Studies
• The Tukey trend test: Multiplicity adjustment using multiple marginal models
• Closed MCP-Mod for pairwise comparisons of several doses with a control
• Model-based dose finding under model uncertainty using general parametric models

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