Thermodynamically Consistent Diffuse Interface Model for Cell Adhesion and Aggregation

Authors Lingyue Shen, Ping Lin, Zhiliang Xu, Shixin Xu

Publication date 15 May 2022

Finite element, Rayleigh-Ritz and Galerkin methods for initial value and initial-boundary value problems involving PDEs (65M60) Three or more component flows (76T30) Physiological flows (76Z05)

Abstract: A thermodynamically consistent phase-field model is introduced for simulating multicellular deformation, and aggregation under flow conditions. In particular, a Lennard-Jones type potential is proposed under the phase-field framework for cell-cell, cell-wall interactions. A second-order accurate in both space and time

C^{0}

finite element method is proposed to solve the model governing equations. Various numerical tests confirm the convergence, energy stability, and nonlinear mechanical properties of cells of the proposed scheme. Vesicles with different adhesion are also used to explain the pathological risk for patients with sickle cell disease.

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